mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis.
Eskandari SK, Allos H, Al Dulaijan BS, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR.
Eskandari SK, et al.
Front Immunol. 2022 Jun 10;13:899975. doi: 10.3389/fimmu.2022.899975. eCollection 2022.
Front Immunol. 2022.
PMID: 35757726
Free PMC article.
Notably, this sequence of signals supports an activated T(reg) phenotype that includes a high expression of granzymes, particularly granzyme B (GrB). Previously, we have shown that aside from the functional effects of GrB in lysing target cells to modulate allo-immunity, G …
Notably, this sequence of signals supports an activated T(reg) phenotype that includes a high expression of granzymes, particularly granzyme …